Angiotensin Converting Enzyme Gene (I/D) Polymorphism And NonalcoholicFatty Liver Disease
2011
Aim: Fibrosis is a finding showing that the process can be progressive
in the spectrum of non-alcoholic fatty liver disease. Activated hepatic
stellate cells cause fibrosis induced by angiotensin II. In this study
the relation between ACE gene (I/D) polymorphism and steatosis,
necroinflammation and fibrosis in liver were investigated. Method: 29
females and 30 males (mean age: 53±10) whose necroinflammatorty
activity and fibrosis scoring in liver biopsies were made according to
Brunt classification were included in the study. According to the
histopathological findings in liver biopsies patients with
non-alcoholic fatty liver disease were determined and ACE gene (I/D)
polymorphism was studied by using genomic DNA isolated from peripheral
blood samples. Result: In patient groups DD genotype frequency was
86.4%, ID genotype frequency was 5.1% and genotype II frequency 8.5%.
In patient there was no significant relation between ACE gene (I/D)
polymorphism, and necroinflammatory activity and fibrosis. Conclusion:
In patients the high frequency of D/D genotype but no association
between necroinflammatory activity and fibrosis suggest that ACE gene
had no role in the development of fibrosis in non-alcoholic fatty liver
disease, however it is a component of general metabolic disorder.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI