Comparative efficacy and safety of basal insulins: A review.

Abstract Background and aim To provide an update on the usefulness of basal insulin in patients with type 2 diabetes mellitus. Methods We conducted a literature search using PubMed and MEDLINE, BIOSIS, Scopus, EMBASE, ClinicalTrials.gov , Google Scholar, and Springer Online Archives Collection until June 2021. Results All basal insulins are similar in efficacy, with only small differences among them in terms of the risk of hypoglycemia. Conclusions For type 2 diabetes mellitus, all basal insulins have a similar efficacy, with some advantage of Glar-300 and Deg-100 in reducing the risk of hypoglycemia compared to Glar-100.