Inactivation of Capicua drives cancer metastasis

Ross A. Okimoto,Frank Breitenbuecher,Victor Olivas,Wei Wu,Beatrice Gini,Matan Hofree,Saurabh Asthana,Gorjan Hrustanovic,Jennifer Flanagan,Asmin Tulpule,Collin M. Blakely,Henry J. Haringsma,Andrew Simmons,Kyle Gowen,James Suh,Vincent A. Miller,Siraj M. Ali,Martin Schüler,Trever G. Bivona

Inactivation of Capicua drives cancer metastasis

2017

Ross A. Okimoto
Frank Breitenbuecher
Victor Olivas
Wei Wu
Beatrice Gini
Matan Hofree
Saurabh Asthana
Gorjan Hrustanovic
Jennifer Flanagan
Asmin Tulpule
Collin M. Blakely
Henry J. Haringsma
Andrew Simmons
Kyle Gowen
James Suh
Vincent A. Miller
Siraj M. Ali
Martin Schüler
Trever G. Bivona

Trever Bivona and colleagues use an in vivo lung cancer metastasis model to show that the transcriptional repressor Capicua (CIC) suppresses invasion and metastasis. CIC inactivation leads to upregulation of ETV4 and MMP24, which is necessary and sufficient for metastasis.

Keywords:

Cancer
Molecular biology
In vivo
Cancer research
Transcriptional Repressor
Lung cancer
Metastasis
Immunology
Downregulation and upregulation
Biology
Tumor progression
Repressor
Effector
Metastasis suppressor

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