Sofosbuvir intermediate and preparation method thereof
2015
The invention provides a sofosbuvir intermediate and a preparation method thereof. The intermediate adopts the structure shown in the specification. The intermediate is prepared from 4-(trifluoromethoxy)phenol and (S)-2-phenoxy-chloro-phosphoryl aminopropionic acid isopropyl ester through a reaction. In a sofosbuvir preparation process, the intermediate has the good splitting effect and is suitable for industrial production, and the overall reaction yield is high.
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