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a systematic review of the surgical and ablative management of breast cancer liver metastasis
2018
1. Abstract 1.1. Background:
Systemic therapy is first line for Breast Cancer Liver Metastasis (BCLM),
though interest in Surgical Resection (SR) and Ablation Therapy (AT) has
increased. We assessed oncologic outcomes after SR and AT in BCLM. 1.2. Methods: A
systematic review identified studies evaluating outcomes for SR and AT for
BCLM. Selected studies reported the following outcomes: Disease-Free Survival (DFS),
Overall Survival (OS), Overall Survival Rate (OSR), Local Recurrence (LR), Complication
Rate (CR) and/or Mortality Rate (MR). 1.3. Results: Sixty-
seven studies were included evaluating 2,259 patients with median age 49.7 years
over follow-up 32.4 months. Median OS and DFS were 43.7 months and 22.8 months
for SR and 40.6 and 23.4 months for AT. Local recurrence for SR was 51.4%
versus 13.9% for AT. CR and MR were 8.8% and 0.04% for AT, versus 17.7% and
0.37% for SR. OSR at 1 and 5 years were 86.8% and 36.9% for SR, and 87.3% and
37.5% for AT. 1.4. Conclusion: This
study is the largest literature review of SR and AT for BCLM, revealing both with
favorable oncologic safety. While a clinical trial may not be feasible, SR and
AT should be considered for BCLM patients. 1. Keywords: Ablation
Therapy; Breast Cancer; Liver Metastasis; Surgical Resection
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