AGA AbstractsMo1669 Correlation Between Serological Biomarkers and Clinical Activity in Patients With Inflammatory Bowel Disease (IBD)

Background: Biomarkers are used routinely to monitor activity in patients with IBD. However, the correlation between these markers and clinical disease activity is not well established. Objectives: To evaluate the correlation between several serological biomarkers and clinical activity in patients with IBD. To identify the serological biomarkers with the best accuracy to assess the clinical activity in patients with IBD. Methods: Patients followed-up at the IBD Unit from our hospital were prospectively included. A blood sample was obtained from each patient and haematological parameters and several biomarkers were determined: C-reactive protein (CRP), orosomucoid, erythrocyte sedimentation rate (ESR), ferritin, and fibrinogen. The clinical activity was assessed by the Partial Mayo Score in the case of ulcerative colitis (UC) and by the Harvey Bradshaw activity index in Crohn’s disease (CD) patients. The accuracy of each biomarker was assessed by the area under the ROC curve (AUC). The best cut-off value for each biomarker was identified; for it, sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) were calculated. Results: Three-hundred and fifty patients were included. The median age was 46 years and the median time of evolution of the disease was 3 years, 52% were female and 59% had CD. The overall accuracy and the accuracy for CD and UC of the best serological biomarkers are shown in the tables.