The Principles of protein surgery and its application to the logical drug design for the treatment of neurodegenerative diseases.

Here we describe the principles of protein surgery and its application to the molecular design for regulating the protein conformation. We initially describe the Poincare duality that defines the basis of complementarity in the time-dependent geometrical space. Next we introduce the theory of protein surgery consisting of "dissection" and "suture," which correspond to differentiation and integration in a phase space, respectively. Then we introduce the surgical (pan-manifold) differential equation and solve several simple cases. In this way, we constructed "medical quantization" strategy which makes a bridge between quantum mechanics and molecular biology. As the application of this theory, here we describe a logical drug design methodology in detail, and its application to anti-prion drug design. Finally, we propose a plan for logical drug (and medical device) design center, in which all the necessary procedures could be done in one place.