Propofol Protects Against High Glucose–Induced Endothelial Apoptosis and Dysfunction in Human Umbilical Vein Endothelial Cells

BACKGROUND:Perioperative hyperglycemia is a common clinical metabolic disorder. Hyperglycemia could induce endothelial apoptosis and dysfunction. Propofol is a widely used IV anesthetic drug in clinical settings. In the present study, we examined whether and how propofol reduced high glucose–induced