CARACTERIZAÇÃO FÍSICO-QUÍMICA DE COMPLEXO DE INCLUSÃO ENTRE HIDROXIMETILNITROFURAZONA E HIDROXIPROPIL-β

Hydroxypropyl-β-cyclodextrin (HP-β-CD) can beused as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize theinclusion complex between NFOH and HP-β-CD. The rate of NFOH release decreases after complexation and thermodynamicparameters from the solubility isotherm studies revealed that a stable complex is formed (∆G