Inhibition of Interleukin‐1β Converting Enzyme by N‐Acyl‐aspartic Acid Ketones.

Adnan M.M. Mjalli,Kevin T. Chapman,Justin J. Zhao,Nancy A. Thornberry,Erin P. Peterson,Malcolm Maccoss

Inhibition of Interleukin‐1β Converting Enzyme by N‐Acyl‐aspartic Acid Ketones.

2010

Adnan M.M. Mjalli
Kevin T. Chapman
Justin J. Zhao
Nancy A. Thornberry
Erin P. Peterson
Malcolm Maccoss

Abstract N-Acyl aspartic acid ketones ( 3a-3n ) were prepared from the corresponding bromomethyl ketone. The inhibition of interleukin-1β converting enzyme (ICE) by these single amino acid ketones is reported. The best compound had K i of 3.5 μM versus ICE.

Keywords:

Aspartic acid
Interleukin
Enzyme
Amino acid
Chemistry
Organic chemistry
interleukin 1β converting enzyme

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