In vitro activity of lomefloxacin against multiply resistant Pseudomonas aeruginosa, enterobacter cloacae, and Staphylococcus epidermidis

Abstract Lomefloxacin is a promising new difluorinated quinolone with good antimicrobial activity and favorable pharmacokinetic properties. The in vitro activity of lomefloxacin was compared to other quinolones, expanded spectrum β-lactams, and gentamicin. The lomefloxacin MIC 90 against multiply resistant strains of P. aeruginosa was 4 mcg/ml, comparable to norfloxacin and ofloxacin. Lomefloxacin was also active against methicillin-resistant S. epidermidis and JK corynebacteria. The role of lomefloxacin in the treatment of infections caused by multiresistant organisms remains to be determined in clinical trials .