Geriatric conditions and treatment burden following diagnosis of non-muscle- invasive bladder Cancer in older adults: A population-based analysis.

Abstract Introduction Treatment burden is emerging as an important patient-centered outcome for older adults with cancer who concurrently manage geriatric conditions. Our objective was to evaluate the contribution of geriatric conditions to treatment burden in older adults with non-muscle invasive bladder cancer (NMIBC). Methods We identified 73,395 Medicare beneficiaries age 66+ diagnosed with NMIBC (Stage Results At baseline, 64% had multimorbidity and median 3 conditions (IQR 0–5). Prevalence of other geriatric conditions ranged from 5.9%–15.2%. Adjusted mean health system contact was 8.9 days (95% CI 8.6–9.2). Multimorbidity had the largest effect size (adjusted mean 11.8 contact days (95% CI 8.3–8.8)). Each additional chronic condition conferred a 13% increased odds of health system contact (adjusted IRR 1.132, 95% CI 1.129–1.135). Regardless of number of chronic conditions, rural patients consistently had more treatment burden than urban counterparts. Discussion In this population-based cohort of older NMIBC patients, multimorbidity and rurality were strongly associated with treatment burden in the year following NMIBC diagnosis. These findings highlight the need for interventions that reduce treatment burden due to geriatric conditions among the growing population of older adults with cancer, particularly in rural areas.