Pharmacokinetic Optimisation of Oral Antifungal Therapy

The range of oral antifungal therapy has been expanded recently by the introduction of itraconazole, fluconazole and terbinaflne. These agents have a broader spectrum of activity than griseofulvin and flucytosine, and induce less liver toxicity than ketoconazole. Treatment with these agents may be optimised by application of pharmacokinetic principles.