Zinc Deficiency Affects the Activity and Protein Concentration of Angiotensin-Converting Enzyme in Rat Testes

AbstractZinc (Zn) deficiency causes hypogonadism in a number of different species. Previous work has shown that Zn deficiency reduces the activity of angiotensin-converting enzyme (ACE), a Zn-dependent enzyme, in the testes of prepubertal rats. These studies were designed to determine whether this effect was caused by a change in the concentration of ACE protein. Thirty-five male rats at 26 days of age were divided into three groups. One group was fed < ad libitum a Zn-adequate diet (40 mg/kg); another group was fed a similar diet, but deficient in Zn (< 1.0 mg/kg); a third group was pair-fed to the deficient group. After 4 weeks on these regimens, all rats in the

Keywords:

• Epididymis
• Zinc
• Enzyme
• Animal model
• Peptidyl-Dipeptidase A
• Endocrinology
• Angiotensin-converting enzyme
• Diabetes mellitus
• Internal medicine
• Testicle
• Biology
• male rats
• protein concentration

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