How to use the PSI Structural Genomics Knowledgebase to Enable Research

The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB, URL: http://kb.psi-structuralgenomics.org) is a web resource designed to turn the products of the structural genomics and structural biology efforts into knowledge that can be used by the biological community to understand living systems and disease. We will present examples and demonstrate how to use the PSI SGKB to enable biological research. For example, a protein sequence or PDB ID search will provide a list of protein structures from the Protein Data Bank, associated biological descriptions (annotations), homology models, structural genomics protein target information, experimental protocols, and the ability to order available DNA clones. A text search will find technology reports and publications that were created by the PSI's high-throughput research efforts. Web tools that aid in bench top research, such as protein construct design, are also available. Created in collaboration with the Nature Publishing Group, the Structural Genomics Knowledgebase Gateway provides a research library, editorials about new research advances, news, and an events calendar also present a broader view of structural genomics and structural biology. The PSI SGKB is funded by the NIGMS.