The Design of a Spiro‐Pyrrolidine Organocatalyst and Its Application to Catalytic Asymmetric Michael Addition for the Construction of All‐Carbon Quaternary Centers.
2015
A novel chiral spiro-pyrrolidine silyl ether organocatalyst has been designed. Its catalytic asymmetric effect is demonstrated by the Michael addition reaction, which affords the desired products with an all-carbon quaternary center in up to 99% ee and 87% yield. Furthermore, the reaction process has been investigated via in situ NMR experiments.
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