High performance liquid chromatographic of Itopride hydrochloride in tablet dosage form

A simple, economical, precise and fast High Performance Liquid Chromatograhic method has been developed for the determination of itopride hidrochloride in tablet dosage form. A phenomenex C18 (Luna) column of length 250 × 7.5 mm with particle size of the stationary phase 5 µm and mobile phase potassium dihydrogen phosphate buffer (pH adjusted to 7.5 with 1M Sodium hydroxide) and acetonitrile in the ratio 60:40 were used in this study. The flow rate was adjusted to 2ml /min and effluent was monitored at 258.0 nm. The proposed method describes the determination of itopride hydrochloride by HPLC, which is a simple, precise and selective.