Evaluation of mono- and dipeptides as organocatalysts for enantioselective aldol reaction
2014
Abstract Catalytic activities of (3 S )-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA)-based mono- and dipeptides and their l -proline analogs in asymmetric aldol reaction were investigated. THIQA-based dipeptides showed better enantioselectivity than proline analogs, whereas proline-based dipeptides gave higher yield in the aldol reaction of cyclohexanone with several aldehydes in dichloromethane at −10 °C in the presence of benzoic acid.
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