c-Src Regulates Mitochondrial Translation by Phosphorylation of Elongation Factor Tu

Mitochondrial dysfunction is involved in the development and progression of diseases including diabetes, Alzheimer's, cardiovascular disease, Parkinson's, and cancer. Therefore, regulation of mitochondrial biogenesis and energy production is important for a properly functioning cell and organism. Phosphorylation is a reversible post-translational modification that is involved in the regulation of many cellular processes, including cell survival and proliferation. Over the last decade, our laboratory has shown the phosphorylation of mitochondrial translation components extensively. Mitochondrial translation plays a fundamental role in energy production due to its role in the synthesis of 13 subunits of the oxidative phosphorylation complexes. In the pursuit of kinases responsible for the Tyr phosphorylation of mitochondrial translation components, c-Src, which is known to be translocated into the mitochondria, was evaluated as a possible Tyr kinase. In this study, we demonstrated that c-Src phosphorylated ...