Paired Filtration Dialysis (PFD):Biocompatibility and Depurative Efficiency

Biocompatibility and depurative efficiency of Paired Filtration Dialysis was evaluated in a short-term (one month) follow up in 12 chronic uremic patients. Plasma granulocyte elastase slightly increased during the first hour of treatment, a transient but significative leukopenia was observed.Protein layer revealed a marked deposition of coagulation factors on polysulphone and trace amount of C3c and immunoglobulins on Hemophane. PFD allows an high depurative efficiency for small molecules (assessed by a Kt/V urea >1) and for Beta-2 MG even in a shorter dialytic time.