Abstract 16793: Association of Impairment of Myocardial Metabolism and Ventricular Arrhythmic Events in Patients With Hypertrophic Cardiomyopathy by Single Photon Emission Computed Tomography With A Solid-state Dedicated Cardiac Camera

Background: Ventricular arrhythmic events have adverse implications for patients with hypertrophic cardiomyopathy (HCM). However, little has been reported on the relationship between myocardial metabolic abnormalities and ventricular arrhythmia. Iodine-123-beta-methyl iodophenyl-pentadecanoic acid (BMIPP) is used to assess myocardial metabolic abnormalities. A solid-state dedicated cardiac camera (D-SPECT) provides precise assessment of abnormal uptake and reduction of radiation dose in HCM by high sensitivity and high spatial resolution. Objective: The aim of this study was to evaluate the utility of BMIPP using D-SPECT for prediction of ventricular arrhythmic events in patients with HCM. Methods: We studied 125 consecutive HCM patients who underwent dual SPECT with D-SPECT using BMIPP and technetium-99m sestamibi (MIBI) or thallium-201 (TL). Reduced uptake on the BMIPP image compared with the MIBI / TL perfusion image was defined as perfusion-metabolic mismatch. In quantitative analysis, a polar map was...