Silver/palladium relay catalyzed 1,3-dipole annulation/allylation reactions to access fully substituted allyl imidazolidines

A silver/palladium relay catalyzed multicomponent reaction of iminoesters and Baylis-Hillman acetates for the construction of fully substituted allyl imidazolidines is reported. This method features high regioselectivity and board substrate scope. The three component reaction is triggered by silver-catalyzed 1,3-dipole annulation, followed by the sequential palladium catalyzed allylation. Mechanistic studies reveal that the dual catalytic system plays the key rule in the reaction. The developed methodology provides straightforward access to allyl imidazolidines under simple reaction conditions.