The value of urine Bence Jones protein and complement C3 in differential diagnosis of nenal amyloidosis and nephrotic syndrome

Objective To explore the differential diagnosis value of urine Bence-Jones protein and complement C3(C3) alone and combined detection in renal amyloidosis and nephrotic syndrome. Methods A total of 115 patients with renal amyloidosis who underwent renal biopsy at the First Affiliated Hospital of Zhengzhou University from January 2014 to December 2017 were enrolled. 32 patients with primary nephrotic syndrome at the same time were randomly selected as controls. Clinical data and laboratory test indicators were collected from the two groups of patients. The receiver operating characteristic curve was used to analyze the value of two indicators of urine Bence-Jones protein and C3 in differential diagnosis of renal amyloidosis and nephrotic syndrome. Results There were significant differences in urine Bence-Jones protein and C3 between patients with renal amyloidosis and nephrotic syndrome. The AUC and 95% CI were 0.826 (0.762, 0.890) and 0.727 (0.634, 0.821), respectively. When the two indicators were combined, the AUC and 95% CI were 0.871 (0.815, 0.926). Conclusions The combined detection of urine Bence-Jones protein and C3 has a high value in the differential diagnosis of renal amyloidosis and nephrotic syndrome. Key words: Urine Bence-Jones protein; Complement C3; Renal amyloidosis; Diagnosis