Differential expressions of carcinoembryonic antigen and squamous cell carcinoma antigen in patients with advanced cervical cancer undergoing chemotherapy.

OBJECTIVE Cervical cancer is a malignant tumor commonly found in women. This study was conducted to discuss the differential expression of carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCCA) in patients with advanced cervical cancer undergoing various chemotherapies and their effects on patient safety. METHODS A total of 65 patients admitted to our hospital with advanced cervical cancer were included as the study subjects and were divided into two groups based on the chemotherapy they received: control group (n = 31) and observation group (n = 34). After two cycles of systemic (IV) chemotherapy in the control group and intra-arterial infusion chemotherapy in the observation group, the two groups were compared for treatment efficacy. RESULTS After chemotherapy, the effective rate was 76.47% in the observation group and 48.39% in the control group (P < 0.05). The CEA and SCCA levels were reduced in the two groups, and the observation group had significantly lower levels than the control group (P < 0.05), and also in patients with CR and PR (P < 0.05). CONCLUSION In patients with advanced cervical cancer, intra-arterial infusion chemotherapy can improve the efficacy and short-and long-term survival, and reduce the serum VEGF level, blood flow in the tumor, metastasis, and reoccurrence.