Synthesis of 2′-β-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors
2005
Abstract Coupling reaction of 2-β- C -methyl-1,2,3,4-tetra- O -benzoyl- d -ribofuranose with 4-amino-6-bromo-5-cyanopyrrolo[2,3- d ]pyrimidine, followed by debromination and debenzoylation, gave the 2′-β- C -methyl toyocamycin in high yield. Based on this result, a series of 2′-β- C -methyl-4-substituted toyocamycin and sangivamycin analogues were synthesized for biological screening as potential inhibitors of HCV RNA replication.
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