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1and2aretheresult ofa100kbpdeletion inthehuman(-globin cluster
1986
TheDNA spanningtwolargedeletionsinthehumanP-globin gene cluster(y thalassaemia 1 and2) hasbeenclonedby cosmidcloningand chromosomal walking. The entireregionwas mappedandanalyzedforthe presenceof repetitivesequences. The resultsshowthattheaffectedloci havelostalmost1OOkbofDNA ina deletioneventnot involvinghomologousor repetitivesequences.
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