Addition conjuguee-alkylation: stereochimie de la reaction des lithiens d'arylacetonitriles sur les cyclenones suivie du piegeage par l'iodure de methyle en une seule operation

Abstract The stereochemistry of trapping of enolates, resulting from reaction of lithiated arylacetonitriles to cyclenones, by methyl iodide, is examined. In a medium such as THF-HMPT , the trans 2,3-disubstituted cyclanones are obtained with good yields, and moreover in nearly all cases alkylation takes place under kinetic control.