Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence
2002
The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of `molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.
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