NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis

Zhaofei Wan,Yan Fan,Xiaojun Liu,Jiahong Xue,Zhenhua Han,Canzhan Zhu,Xinhong Wang

NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis

2019

Zhaofei Wan
Yan Fan
Xiaojun Liu
Jiahong Xue
Zhenhua Han
Canzhan Zhu
Xinhong Wang

Background NLRP3 inflammasome can be activated by high glucose and links inflammation and metabolic disease. This study aimed to investigate the role of NLRP3 inflammasome in hyperglycemia-induced endothelial inflammation and diabetic atherosclerosis.

Keywords:

Diabetes mellitus
Immunology
Inflammation
Inflammasome
Medicine
Endocrinology
Internal medicine
Umbilical vein
Cell adhesion molecule
Peripheral blood mononuclear cell
Receptor antagonist
Gene knockdown

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