Late toxicity and quality of life in oral cavity and oropharyngeal cancer survivors treated with chemoradiotherapy.

9092 Background: Concurrent chemoradiotherapy (CRT) in unresectable head and neck cancer (HNC) leads to a better loco-regional control and an overall survival benefit over RT alone, but an increased toxicity is also seen. Late effects are often persistent and may affect the long term health related quality of life (HRQL) of HNC survivors. Objectives: (a) Identify the prevalence of clinical late toxicities (cLT) grade≥2 in oral cavity (OrC) and oropharyngeal (OrP) cancer survivors after CRT. (b) Assess HRQL in this population. (c) Explore potential associations between (a) and (b). Methods: Patients (pts) who were disease-free at least 1 year after CRT were eligible for this cross-sectional study. cLT was assessed by physical exam and graded according to NCI-CTCAE v.3; nutritional status was assessed by body mass index; and HRQL by the EORTC QLQ-C30 and QLQ-H&N35 cancer module questionnaires. The results were compared with the EORTC QLQ-C30 Reference Values (RV) for the general population. Results: 40 pts ...