Treatment of Severe Acute Renal Failure with Continuous Renal Replacement Therapy and Intermittent Hemodialysis

Objective To investigate the efficacy of continuous renal replacement therapy(CRRT) versus intermittent hemodialysis(IHD) in severe acute renal failure(ARF) patients. Methods Seventy|five severe ARF were recruited in this study. Of them, 33 cases were treated with CRRT(CRRT group) and 42 cases with IHD(IHD group). Results Patients in CRRT group were more severely ill as manifested by a lower mean arterial pressure, higher APACHE Ⅱ score, more dysfunctioned organs and more frequent requirement of mechanical ventilation and vasopressor support as compared with patients in IHD group. 24(72 7%) patients in CRRT group survived on the acute phase of the illness and 9(27 3%) patients died, while 23(54 8%) patients in IHD group survived and 19(45 2%) patients died, significant difference in survival was found between the two groups. Conclusion CRRT is the first choice in the treatment of severe ARF patients, for it can offer several distinct advantages and improved survival, particularly in the more severely ill patients.