Cohort Study of the Long-Term Effect of Irradiation for Carcinoma of the Uterine Cervix: Second primary malignancies in the pelvic organs in women irradiated for cervical carcinoma at Radiumhemmet 1914–1965

The risk of second primary malignancy arising after therapeutic irradiation was evaluated in the Radiumhemmet series of carcinoma of the uterine cervix treated in 1914–1965. Only tumours appearing more than 10 years after irradiation were taken into account. Comparisons of observed with expected incidence showed excess of malignancies in urinary bladder, endometrium, ovaries and rectum, but not of colon carcinoma. Comparisons were made with cohorts from the Swedish Cancer Registry.