ON THE PHARMACOLOGICAL ACTION OF ALLOCAIN S. (A NEW LOCAL ANESTHETIC)

1. Allocain S. causes paralysis in frogs and convulsions in rabbits, acting upon the central nervous system. 2. The lethal dose of Allocain S. when injected subcutaneously is for frogs 0.0004 gram per gram body weight, and for rabbits 0.6 gram per kilogram weight, and is smaller than that of cocain and novocain. 3. Allocain S. causes a local paralysis of the sensory nerve endings and nerve fibres, and its anesthetic power is stronger than novocain and weaker than cocain. 4. Allocain S. has a two-fold action upon blood vessels; a primary dilation and a secondary constriction, and in warm blooded animals the former action, and in cold blooded animals the latter appears more marked. 5. Subcutaneous injections of Allocain S. cause a slight local irritation. 6. A great amount of Allocain S. paralyses the heart, acting upon the motor apparatus and conductive system, and causes in frogs a paralysis of respiration and in rabbits a stimulation of it, which action seems to be central in character. 7. The blood pressure is influenced by Allocain S. The substance produces a primary fall of pressure which is followed by a rise above the normal. 8. Allocain S. inhibits the growth of both strepto- and straphy-lococci. 9. Allocain S. has a good character as a local anesthetic in many respects, but on the other hand it has also some unfavorable qualities. On account of the slight irritation by its acid solutions and of its precipitation by tissue fluids, its use is limited.