Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx

Tetsuya Fukuta,Hideshi Okada,Genzou Takemura,Kodai Suzuki,Chihiro Takada,Hiroyuki Tomita,Akio Suzuki,Kazumasa Oda,Akihiro Uchida,Saori Matsuo,Hirotsugu Fukuda,Hirohisa Yano,Isamu Muraki,Ryogen Zaikokuji,Ayumi Kuroda,Ayane Nishio,So Sampei,Nagisa Miyazaki,Yasuaki Hotta,Noriaki Yamada,Takatomo Watanabe,Kentaro Morishita,Tomoaki Doi,Takahiro Yoshida,Hiroaki Ushikoshi,Shozo Yoshida,Yoichi Maekawa,Shinji Ogura

Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx

2019

ABSTRACTMyocardial injury in sepsis may be caused by a burst of several inflammatory mediators, leading to vascular endothelial injuries. However, the contribution of neutrophil elastase (NE) to myocardial injury in sepsis is still unknown. We aimed to evaluate whether endotoxaemia-induced myocardia

Keywords:

Neutrophil elastase
Immunology
Glycocalyx
Diabetes mellitus
Sepsis
Medicine

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