Immunisation leucocytaire et avortements spontanés précoces.

: Forty patients who had had at least two early spontaneous abortions, i.e. before the 12th week of pregnancy without known aetiology factors (anatomical, chromosomal, infectious or hormonal) were immunised with their husband's leucocytes. These immunisations were carried out by repeated intravenous injections of leucocytes taken from the husband's peripheral blood. In 24 patients the search for anti-HLA antibodies was shown to be positive after a varying number of injections (2 to 10). Twelve patients are still being treated, 4 did not make antibodies. Eighteen pregnancies have been observed, of whom 11 have so far come to term, 4 are following a normal course and 3 pregnancies were interrupted late of different reasons. The success rate, by which is meant pregnancies without early abortion, was 17/21, i.e. 81%. A comparison of the number of HLA A, B or DR antigens found to be shared between the couple in 40 couples studied, when compared with a series of 64 fertile couples (who had had at least 2 children without any abortions) shows no differences. These couples as compared with fertile couples do not show either differences in the frequency of HLA antigens. After leucocyte immunisation an inhibition in the mixed lymphocyte culture is found between the patient's lymphocytes and her husband's in the wife's serum if this has made anti-HLA antibodies.