Missed Insulin Meal Boluses and Elevated Hemoglobin A1c Levels in Children Receiving Insulin Pump Therapy

Objective. To identify possible causes of suboptimal glycemic control (ascertained by hemoglobin A 1c [HbA 1c ] level) in youths using insulin pump therapy. Methods. Forty-eight youths who were receiving insulin pump therapy for ≥6 months, and who were using insulin pumps and blood glucose meters with data that could be downloaded at our facility, are included in this cross-sectional study. Possible causes of suboptimal glycemic control were evaluated by using 4 information sources: 1) insulin pump data downloads; 2) glucose meter data downloads; 3) patient/family questionnaire about insulin bolusing habits, eating habits, exercise, and blood glucose testing habits; and 4) a physician questionnaire. Physicians completed the questionnaire during the patient interview after reviewing the downloaded information and discussing these results with the patient/family. Results. The mean (± standard deviation) age of participants was 15.3 (±3.0) years (range: 7–20 years), and the mean (± standard deviation) duration of type 1 diabetes and continuous subcutaneous insulin infusion was 8.2 (±4.0) and 1.9 (±1.0) years, respectively. Patients who missed 1c level of 8.0% (7.7, 8.3), whereas those who missed ≥1 mealtime boluses per week had a mean HbA 1c level (95% confidence interval) of 8.8% (8.6, 9.1). No significant relationships were found between HbA 1c levels in males and females, the amount of exercise per week, or bolusing before insulin pump disconnection for exercise. Although not significant, a trend was found for those who missed 1c levels. Significant correlations were found between HbA 1c levels and the number of missed mealtime boluses per week ( r = .414) and mean blood glucose levels ( r = .70). Conclusion. Missed mealtime insulin boluses seem to be the major cause of suboptimal glycemic control in youths with diabetes receiving continuous subcutaneous insulin infusion therapy.