Changes in cell fate methods

The present invention discloses a method of altering cell fate, construct, a cell HP1a heterochromatin protein expression and localization in the cell for changing method of changing cellular chromatin structure, means for altering the cellular histone H3 A the method and cell of the base. Wherein altered cell fate method comprising contacting said cell over-expressing a selected one of the following amino acid sequence of a protein: (a) SEQ ID NO: of at least one of the amino acid sequence shown in FIG. 1 to 3; (b) SEQ ID NO: 1 to 3, a portion of at least one of the amino acid sequence shown; (c) to (a) or (b), an amino acid sequence having at least 80% amino acid sequence identity. Using this method enables cells overexpressing Gadd45 family proteins, chromatin can be effectively open cells, it can be easily and effectively alter cell fate in particular to promote reprogramming somatic cells.