The partial region polypeptide REIC / Dkk-3 protein

Object of the present invention is to provide a potent inducer, activated dendritic cell-like cells and polypeptides for treating or preventing cancer by immunotherapy; and DNA encoding the polypeptide, the polypeptide is the following (a) or (b ) by the partial region polypeptide REIC / Dkk-3 protein consisting of: (a) one kind of a partial region polypeptide REIC / Dkk-3 protein composed of that selected from the group consisting of SEQ ID NO 3, SEQ ID 5, SEQ ID NO 7 group and an amino acid sequence amino acid sequence shown in SEQ ID NO 9, and the amino acid sequence of a polypeptide fragment consisting of the following partial region consisting of configuration, the 135 amino acid sequence of the partial region shown in SEQ ID NO 2 the Ser to Ile at position 350 constituting fragment containing the partial region of the amino acid sequence of SEQ ID NO Gly 2 shown in position 205 to 288 of the partial region configured Phe; (b) having a single monocytes differentiate into dendritic differentiation activity of the polypeptide to induce cell-like cells, which is 3, SEQ ID 5, SEQ ID NO 7 and 9 in the amino acid sequence shown in SEQ ID NO selected from the group consisting of SEQ ID, and the following partial region by The amino acid sequence of the group consisting of amino acid sequence of a polypeptide consisting of a fragment of one or several amino acids are substituted, deleted or added amino acid sequence of a polypeptide constituting a protein, the amino acid sequence shown in the partial region of SEQ ID NO Ser at position 135 to position 350 is Ile configuration, the partial segment region containing the amino acid sequence of Gly shown in SEQ ID NO 2 of the partial region 205 to the 288th Phe thereof.