Pharmaceutical Standardisation of Devdarvadyarishta w.s.r to the Fermenting Vessel

Standard operating procedure for pharmaceutical preparation of Devdarvadyarishta has been developed in the present research work. A pilot scale study having 3 batches was carried out initially to find out the best possible fermenting vessel among glass jar, porcelain jar and stainless steel vessel and also to investigate for any possible hurdle related with fermentation process as honey and not jaggery is used as sweetening agent in this formulation. Three samples of Devdarvadyarishta as per conventional method were prepared in accordance with Bhaishjya Ratnavali and process for standard of Devdarvadyarishta was set in as a Quality specification for the same. Porcelain jar was found to be the best as per the results of pilot study as evident by alcohol content of 5.73%, 6.25% and 6.10% respectively in glass jar, porcelain jar and stainless steel vessel, the reaction being completed in between 38-47 days.  Approximate duration of Kwatha formation in all the batches was 9 hours with peak temperature during boiling being maintained at 920C. In all the three batches, fermentation started on 7th day, 7th day and 9th day, total duration of fermentation was 72 days, 70 days and 75 days, with % loss of 15.78%, 17.76% and 19.07% respectively. Mean % loss observed during preparation was 17.53%.