Mechanical Adjustment Tissue Engineered Human Auricular Cartilage Shape and Elasticity In Vitro

Purposes: This study is to establish an adjustable environment for culturing the functional human auricular cartilage shape in vitro. Methods: Physical stimulation affects chondrocytes function. Therefore, bioreactors have been designed in vitro to transmit a novel perfussion-compression loading and can stretch and maintain the construct's size and ear-specific shape. Results: It could provide cultures with multimechanical adjustment complex mechanical environment of a normal human auricular cartilage. Conclusions: We propose that this comprehensive perfusion-compression loading bioreactor can enhance the cultivation of shaping and elastic human auricular cartilage constructs in vitro.