Synthesis and Biological Activity of Substituted-4,5,6,7-tetrahydrothieno Pyridines: A Review
2014
4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno
pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired
findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the
development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical
development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to
organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till
date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis
on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs.
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