Black tea polyphenols protect against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

Dietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: black tea polyphenols (Polyphenon-B)Outcome studied: buccal pouch (HBP) carcinogenesis / expression of proliferating cell nuclear antigen (PCNA) in the buccal pouch / concentration of lipid peroxides, protein carbonyl / antioxidant status in the buccal pouch, liver and erythrocytesStudy type: hamstersTissue/biological material/sample size: buccal pouch, liver, bloodMode of exposure: dietaryImpact on outcome (including dose-response): Dietary administration of Polyphenon-B effectively suppressed DMBA-induced HBP carcinogenesis as revealed by decreased incidence of tumours and PCNA expression. In addition, Polyphenon-B modulated lipid and protein oxidation and enhanced the antioxidant status in the pouch, liver, and erythrocytes.