Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Lu et al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading to reactive gliosis in Drosophila.