Association of Fcγ Receptor IIa Genotype With Chronic Periodontitis in Caucasians

Background: Functional polymorphisms of immunoglobulin G (IgG) Fc receptors IIIa and IIIb (FcγRIIIa and FcγRIIIb) have been shown as risk factors for periodontitis. The aim of this study is to examine whether FcγRIIa polymorphism is associated with a disease risk as well. Methods: Baseline periodontal and general health examinations were carried out on 1,221 Caucasian adults. From these, 422 subjects with moderate to severe, or little or no periodontal disease were assigned to two groups according to their mean clinical attachment loss (CAL). Subjects with mean CAL ≥2.94 mm were diagnosed with chronic periodontitis (n = 213, 62 never-smokers and 151 smokers). Subjects with mean CAL ≤1.77 mm were considered as having little or no periodontal disease and designated as controls (n = 209, 125 never-smokers and 84 smokers). The FcγRIIa genotype for three bi-allelic polymorphisms (FcγRIIa-R/ R131, R/H131, and H/H131) was determined by means of allelespecific polymerase chain reactions. Results: The distribution...