Device-detected non-sustained ventricular tachycardia in adult congenital heart disease without tetralogy of fallot.

OBJECTIVES To evaluate any association between non-sustained ventricular tachycardia (NSVT) detected by intra-cardiac device and clinical outcomes in repaired adult congenital heart disease (ACHD) without tetralogy of Fallot (TOF). BACKGROUND NSVT portends a higher risk of serious ventricular tachyarrhythmia in TOF. However its clinical significance when incidentally detected by implantable cardiac device is not well elucidated in non-TOF ACHD cohort. METHODS We performed a single center, retrospective, longitudinal follow-up study in repaired ACHD (≥ 18 years) patients without TOF who hosted a pacemaker or automatic implantable cardiac defibrillator (AICD). The cohort was divided based on presence/absence of device detected NSVT. The primary end-point was a composite of sustained ventricular tachycardia (VT), ventricular fibrillation (VF), or sudden cardiac death (SCD). RESULTS 158 patients [male 56.3%, median (IQR) age of 35 (28-43) years at last follow-up] with longitudinal post-implant follow-up duration of 8 (5-12) years were included. NSVT was detected in 52 (33%) patients. The primary composite end-point was more frequent in NSVT group [11.5% vs. 2.8%; p = 0.04]. Patients with NSVT were i) older at the time of initial implant (age 25 vs. 18 years, p = 0.011) and more frequently demonstrated ii) systemic ventricular dysfunction (44% vs. 26%; p = 0.015), as well as iii) history of ventriculotomy (38% vs. 21%;p = 0.017). CONCLUSIONS In our repaired ACHD cohort, we noted a significant association between device-detected-NSVT and the primary composite end-point of sustained VT/VF or SCD. Systemic ventricular dysfunction and history of ventriculotomy were more frequent in the NSVT group and likely constituted the clinical milieu. This article is protected by copyright. All rights reserved.