Antimicrobial and anti-inflammatory compounds from a marine fungus Pleosporales sp.

Abstract Seven new compounds, pleosporallins A–G ( 1 – 7 ), were isolated from Pleosporales sp., a fungus derived from a marine alga Enteromorpha clathrata . The structures of these compounds were elucidated by an extensive analysis of NMR, MS, CD spectra, and single crystal X-ray diffraction. Compounds 4 and 5 showed antimicrobial activity with their MIC values of 9.48 μg/ml and 7.44 μg/ml against Clavibacter michiganense subsp. Sepedonicus and Candida albicans , respectively. Compounds 1 – 3 exhibited moderate inhibitory activities against the lipopolysaccharide (LPS)-induced intracellular IL-6 production of murine macrophage cell line RAW264.7.