Divergent Strategy for the Synthesis of α2-3-Linked Sialo-oligosaccharide Libraries Using a Neu5TFA-(α2-3)-Gal Building Block

A novel Neu5TFA-(α2-3)-Gal building block with removable protecting group at N5′ was introduced and used in the divergent synthesis of a library of N -acetyl and N -glycolyl derivatives of oligosaccharides related to sialyl-(α2-3)- N -acetyl-lactosamine and sialyl-(α2-3)- N -acetyl-isolactosamine, with or without sulfate at O6 of glucosamine residue.