A diversity-oriented-synthesis protocol for scaffold discovery based on a general synthetic route to spirocycles
2011
Abstract A diversity-oriented synthesis (DOS) protocol for scaffold discovery is described. A general synthetic route is developed from a single lactam for the access to various multi-functionalized spirocyclic keto-lactams and their derived spirocyclic keto-amines. This work provides the foundation for a sequential DOS strategy from scaffold discovery to drug discovery.
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