ASSOCIATION OF RS17366743 POLYMORPHIC MARKER OF ADIPONECTIN GENE WITH TYPE 2 DIABETES MELLITUS IN HABITANTS OF BASHKORTOSTAN

Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern world. The disease is characterized by high ratio of micro- and macrovascular complications. T2DM is a multifactorial and polygenic disease, structure of hereditary predisposition to which may be population-specific. Aim — the analysis of allelic associations of adiponectin gene ( ADIPOQ, rs17366743 ) with T2DM, its clinical and metabolic characteristics and complications in T2DM patients resident in the Republic of Bashkortostan. Material and methods. 3 PCR-based method of genotyping with polymorphic marker rs17366743 of ADIPOQ gene in 433 T2DM patients and 428 healthy controls, residents of Bashkortostan. Results. The ratio of genotype CT and allele С was higher in T2DM patients compared with controls (15.7% vs. 6.8%; p =0.0002 and 7.8% vs. 3.4%; p <0.0001, respectively). Genotype ТТ and allele Т were less frequent in T2DM than in healthy subjects (84.3 and 93,2%; p =0.0002; 92.2 and 96.6%, p <0.0001, respectively). The association with the development of diabetic retinopathy and cataract was shown ( p =0,044, p =0,008, respectively). Conclusions. Allele C and genotype CT are risk markers of T2DM (OR=2.43 and 2.56 respectively).