Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres
2019
The dystrophin-glycoprotein complex (DGC) links the muscle cytoskeleton to the
extracellular matrix and is responsible for force transduction and protects the muscle fibres
from contraction induced damage. Mutations in components of the DGC are responsible for
muscular dystrophies and congenital myopathies. Expression of DGC components have been
shown to be altered in many myopathies. In contrast we have very little evidence of
whether adaptive changes in muscle impact on DGC expression. In this study we
investigated connection between muscle fibre phenotype and the DGC. Our study reveals
that the levels of DGC proteins at the sarcolemma differ in highly glycolytic muscle
compared to wild-type and that these changes can be normalised by the super-imposition of
an oxidative metabolic programme. Importantly we show that the metabolic properties of
the muscle do not impact on the total amount of DGC components at the protein level. Our
work shows that the metabolic property of a muscle fibre is a key factor in regulating the
expression of DGC proteins at the sarcolemma.
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